Vortioxetine: uses, side effects & brands

Written & medically reviewed by Dr. Sanjay Anbu, MBBS · Last reviewed 5 November 2026

Vortioxetine is a newer antidepressant that may also help concentration. It belongs to the Antidepressant (extra) group. More antidepressants and related mood medicines, each suited to different situations.

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Drug type — dosing is set by your doctor

Measure	Range
Drug class	Antidepressant (extra)
Type	Prescription
Dose	Individual — ask your doctor or pharmacist

What it is used for

Depression (major depressive disorder)
Preventing depression from returning
Depression with poor concentration

Common brand names

India: Vortifar, Estiva
Worldwide: Trintellix, Brintellix

Common side effects

Nausea
Itching
Constipation or diarrhoea
Unusual dreams

Before taking it — precautions

Never combine with MAOI antidepressants; mention other antidepressants or tramadol
Tell your doctor about bleeding problems or blood-thinner use
Discuss with your doctor if pregnant or breastfeeding

When to see a doctor urgently

Suicidal thoughts or worsening mood (urgent)
Agitation, fever, shaking and fast heartbeat (serotonin syndrome) (urgent)
Unusual bleeding or bruising

Not a prescription — no dose shown. The right dose of vortioxetine depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.

Frequently asked questions

Does the nausea go away?

Nausea is the most common side effect and usually settles within the first couple of weeks. Taking it with food can help.

Does it really help concentration?

Some studies suggest it may improve thinking and focus in depression, but it is mainly an antidepressant.

How long before I feel better?

Most people notice improvement after a few weeks. Keep taking it as prescribed even if you feel better.

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Sources & further reading

Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.