Clomipramine: uses, side effects & brands

Written & medically reviewed by Dr. Sanjay Anbu, MBBS · Last reviewed 5 November 2026

Clomipramine is a tricyclic used especially for OCD and depression. It belongs to the Antidepressant (extra) group. More antidepressants and related mood medicines, each suited to different situations.

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Drug type — dosing is set by your doctor

Measure	Range
Drug class	Antidepressant (extra)
Type	Prescription
Dose	Individual — ask your doctor or pharmacist

What it is used for

Obsessive-compulsive disorder (OCD)
Depression
Panic disorder and phobias
Cataplexy linked to narcolepsy

Common brand names

India: Clonil, Clomfranil
Worldwide: Anafranil

Common side effects

Dry mouth and constipation
Drowsiness and dizziness
Sweating and weight gain
Sexual problems

Before taking it — precautions

Not for people who recently had a heart attack; tell your doctor about heart, glaucoma, prostate or seizure problems
Never combine with MAOI antidepressants; caution with other antidepressants
Very dangerous in overdose; keep away from children

When to see a doctor urgently

Suicidal thoughts or worsening mood (urgent)
Fast or irregular heartbeat, fainting (urgent)
Fever, stiffness, confusion or a seizure (urgent)

Not a prescription — no dose shown. The right dose of clomipramine depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.

Frequently asked questions

Why is clomipramine used for OCD?

It has a strong effect on serotonin, which helps reduce obsessions and compulsions more than most other tricyclic antidepressants.

How long until it works?

Some benefit may show in a few weeks, but OCD symptoms often take several weeks to a few months to improve fully.

Can I stop it suddenly?

No. Stopping suddenly can cause flu-like symptoms, poor sleep and irritability; your doctor will reduce it gradually.

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Sources & further reading

Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.