Imipramine: uses, side effects & brands

Written & medically reviewed by Dr. Sanjay Anbu, MBBS · Last reviewed 5 November 2026

Imipramine is a tricyclic antidepressant also used for bedwetting and nerve pain. It belongs to the Antidepressant (extra) group. More antidepressants and related mood medicines, each suited to different situations.

Ask MedDroid about imipramine →

Drug type — dosing is set by your doctor

Measure	Range
Drug class	Antidepressant (extra)
Type	Prescription
Dose	Individual — ask your doctor or pharmacist

What it is used for

Depression
Bedwetting in children (when other measures fail)
Nerve pain (off-label)
Panic disorder

Common brand names

India: Depsonil, Antidep
Worldwide: Tofranil

Common side effects

Dry mouth and constipation
Drowsiness
Dizziness on standing
Blurred vision

Before taking it — precautions

Tell your doctor about heart disease, glaucoma, prostate trouble or seizures
Never combine with MAOI antidepressants; avoid alcohol
Very dangerous in overdose; store safely away from children

When to see a doctor urgently

Suicidal thoughts or worsening mood (urgent)
Fast or irregular heartbeat, fainting (urgent)
Difficulty passing urine or severe constipation

Not a prescription — no dose shown. The right dose of imipramine depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.

Frequently asked questions

Is imipramine safe for children who wet the bed?

It can help some children, but it is usually tried only after alarms and other measures, and must be kept locked away because overdose is dangerous.

Why does it make my mouth dry?

Imipramine blocks a nerve chemical that controls saliva. Sipping water and sugar-free gum can help.

Is it the same as amitriptyline?

Both are older tricyclic antidepressants with similar side effects, but they are different medicines and are not swapped without a doctor.

Ask MedDroid about imipramine →

Explore more

Sources & further reading

Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.