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Methylprednisolone: uses, side effects & brands
Methylprednisolone is a steroid for inflammation, given as tablets or injection. It belongs to the Systemic corticosteroid (extra) group. These steroids strongly reduce inflammation and calm the immune system in many conditions.
Drug type — dosing is set by your doctor
| Measure | Range |
|---|---|
| Drug class | Systemic corticosteroid (extra) |
| Type | Prescription |
| Dose | Individual — ask your doctor or pharmacist |
What it is used for
- Flare-ups of autoimmune and inflammatory diseases (e.g. rheumatoid arthritis, lupus)
- Relapses of multiple sclerosis (high-dose drip in hospital)
- Severe allergic reactions, asthma and skin conditions
- Joint injections for local inflammation
Common brand names
- India: Medrol, Solu-Medrol
- Worldwide: Medrol, Depo-Medrol
Common side effects
- Increased appetite and weight gain
- Raised blood sugar
- Mood changes or trouble sleeping
- Stomach irritation
Before taking it — precautions
- Do not stop suddenly after long use; the dose is tapered by the doctor
- Tell the doctor about diabetes, TB, stomach ulcers, glaucoma or high blood pressure
- Avoid live vaccines and contact with chickenpox or measles while on it
When to see a doctor urgently
- Fever or signs of infection that will not settle
- Black stools or vomiting blood (urgent)
- Severe mood change, confusion or thoughts of self-harm (urgent)
Frequently asked questions
Is methylprednisolone the same as prednisolone?
They are closely related steroids with very similar effects; methylprednisolone is also available as a hospital injection.
Why must the dose be reduced slowly?
Long use switches off your body's own steroid production, so stopping suddenly can make you very unwell.
Will it raise my sugar?
It often does. People with diabetes should check sugars more often while on it.
Explore more
Sources & further reading
- World Health Organization (WHO)
- MedlinePlus — U.S. National Library of Medicine
- Ministry of Health & Family Welfare, India
- Indian Council of Medical Research (ICMR)
Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.