Written & medically reviewed by Dr. Sanjay Anbu, MBBS· Last reviewed
Methotrexate is a weekly DMARD for rheumatoid arthritis, psoriasis and some cancers. It belongs to the Immunosuppressant / DMARD group. These calm an overactive immune system in autoimmune diseases and after transplants.
Regular blood tests to monitor blood counts, liver and kidneys
Avoid live vaccines; report infections early
Methotrexate is taken WEEKLY, not daily, with folic acid
When to see a doctor urgently
Fever, sore throat or infection (weakened immunity)
Breathlessness or persistent cough
Yellow eyes, easy bruising or unusual bleeding
Not a prescription — no dose shown. The right dose of methotrexate depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.
Frequently asked questions
Why is methotrexate taken once a week?
For arthritis and psoriasis it is a weekly dose — taking it daily by mistake can be dangerous. Folic acid is added on other days to reduce side effects.
Are these medicines dangerous?
They need monitoring because they lower immunity and can affect blood, liver and kidneys — but for serious autoimmune disease the benefits usually outweigh the risks.
Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.