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Methotrexate: uses, side effects & brands
Methotrexate is a weekly DMARD for rheumatoid arthritis, psoriasis and some cancers. It belongs to the Immunosuppressant / DMARD group. These calm an overactive immune system in autoimmune diseases and after transplants.
Drug type — dosing is set by your doctor
| Measure | Range |
|---|---|
| Drug class | Immunosuppressant / DMARD |
| Type | Prescription |
| Dose | Individual — ask your doctor or pharmacist |
What it is used for
- Treats rheumatoid arthritis and other inflammatory arthritis
- Treats severe psoriasis
- Used in Crohn's disease and some other autoimmune conditions
- Treats some cancers at much higher doses
Common brand names
- India: Folitrax, Imutrex, Methocip
- Worldwide: Trexall, Otrexup
Common side effects
- Nausea or loss of appetite
- Mouth ulcers
- Tiredness
- Hair thinning
Before taking it — precautions
- For arthritis and psoriasis it is taken once a WEEK, not daily; taking it daily can be fatal
- Regular blood tests check blood counts, liver and kidneys; avoid alcohol and tell your doctor about all medicines, especially certain antibiotics
- Not to be used in pregnancy; reliable contraception is needed, and folic acid is usually prescribed
When to see a doctor urgently
- Fever, sore throat, mouth ulcers or unusual bruising (urgent)
- New cough or breathlessness (urgent)
- Yellow skin or eyes, or dark urine
Not a prescription — no dose shown. The right dose of methotrexate depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.
Frequently asked questions
Why is it taken only once a week?
For arthritis and psoriasis, the weekly schedule is safe; taking it daily by mistake can cause serious harm.
Why do I take folic acid?
Folic acid reduces side effects such as nausea and mouth ulcers.
Can I drink alcohol?
Limit or avoid alcohol, as it increases the risk of liver damage.
Explore more
Sources & further reading
- World Health Organization (WHO)
- MedlinePlus — U.S. National Library of Medicine
- Ministry of Health & Family Welfare, India
- Indian Council of Medical Research (ICMR)
Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.