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Leflunomide: uses, side effects & brands
Leflunomide is a DMARD for rheumatoid and psoriatic arthritis. It belongs to the Immunosuppressant / DMARD group. These calm an overactive immune system in autoimmune diseases and after transplants.
Drug type — dosing is set by your doctor
| Measure | Range |
|---|---|
| Drug class | Immunosuppressant / DMARD |
| Type | Prescription |
| Dose | Individual — ask your doctor or pharmacist |
What it is used for
- Treats rheumatoid arthritis
- Treats psoriatic arthritis
- Slows joint damage in inflammatory arthritis
Common brand names
- India: Lefno, Cleft, Lefra
- Worldwide: Arava
Common side effects
- Diarrhoea
- Raised blood pressure
- Hair thinning
- Raised liver enzymes
Before taking it — precautions
- Not to be used in pregnancy; it stays in the body a long time, so a washout procedure may be needed before conceiving
- Regular blood tests and blood-pressure checks are needed; avoid alcohol
- Tell your doctor about liver disease or other medicines that affect the liver
When to see a doctor urgently
- Yellow skin or eyes, or dark urine (urgent)
- Fever, sore throat or signs of infection
- New cough or breathlessness (urgent)
Not a prescription — no dose shown. The right dose of leflunomide depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.
Frequently asked questions
Why is pregnancy a concern?
Leflunomide can harm an unborn baby and stays in the body for a long time, so planning is needed.
What is a washout?
A medicine can be given to help remove leflunomide from the body faster when needed.
How long until it works?
It usually takes several weeks to show benefit.
Explore more
Sources & further reading
- World Health Organization (WHO)
- MedlinePlus — U.S. National Library of Medicine
- Ministry of Health & Family Welfare, India
- Indian Council of Medical Research (ICMR)
Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.