Doxylamine: uses, side effects & brands

Written & medically reviewed by Dr. Sanjay Anbu, MBBS · Last reviewed 5 November 2026

Doxylamine is a sedating antihistamine used for occasional sleeplessness and pregnancy nausea (with B6). It belongs to the Sleep & sedative (non-benzodiazepine) group. These help short-term sleep problems; most are for brief use to avoid dependence.

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Drug type — dosing is set by your doctor

Measure	Range
Drug class	Sleep & sedative (non-benzodiazepine)
Type	Prescription
Dose	Individual — ask your doctor or pharmacist

What it is used for

Occasional sleeplessness
Nausea and vomiting in pregnancy, combined with vitamin B6
Some cold and allergy combinations

Common brand names

India: Doxinate (with B6), Restwel
Worldwide: Unisom

Common side effects

Next-day drowsiness
Dry mouth
Constipation
Blurred vision

Before taking it — precautions

Avoid alcohol and other sedatives
Tell the doctor about glaucoma, prostate enlargement, asthma or sleep apnoea
Older people may become confused; not for young children without advice

When to see a doctor urgently

Unable to pass urine
Confusion, fast heartbeat or hallucinations (urgent)
Extreme sleepiness or difficulty waking (urgent)

Not a prescription — no dose shown. The right dose of doxylamine depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.

Frequently asked questions

Is the doxylamine–B6 combination safe in pregnancy?

Yes, it has been widely used and studied for morning sickness and is considered safe when prescribed.

Can I drive after taking it?

Not if you feel drowsy; effects can last into the next morning.

Is it addictive?

It is not a typical habit-forming sleeping pill, but tolerance develops and it is meant for occasional use.

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Sources & further reading

Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.