Sodium Valproate: uses, side effects & brands

Written & medically reviewed by Dr. Sanjay Anbu, MBBS · Last reviewed 5 November 2026

Valproate controls several seizure types and stabilises mood; avoided in pregnancy. It belongs to the Anti-epileptic (seizure medicine) group. These control seizures in epilepsy and are sometimes used for nerve pain or mood.

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Drug type — dosing is set by your doctor

Measure	Range
Drug class	Anti-epileptic (seizure medicine)
Type	Prescription
Dose	Individual — ask your doctor or pharmacist

What it is used for

Many types of epilepsy
Bipolar disorder (mania)
Preventing migraine (specialist use)

Common brand names

India: Valparin, Encorate, Divaa
Worldwide: Depakote, Epilim

Common side effects

Nausea or stomach upset
Weight gain
Tremor
Hair thinning

Before taking it — precautions

Must not be used in girls and women who could become pregnant unless no alternative and a pregnancy prevention plan is in place (serious birth defects)
Tell your doctor about liver disease or metabolic disorders; liver tests are needed
Do not stop suddenly; tell your doctor about other seizure medicines and aspirin

When to see a doctor urgently

Yellow eyes or skin, dark urine or severe vomiting (liver injury, urgent)
Severe stomach pain spreading to the back (pancreatitis, urgent)
Unusual bruising or bleeding, or drowsiness with confusion

Not a prescription — no dose shown. The right dose of sodium valproate depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.

Frequently asked questions

Why is valproate dangerous in pregnancy?

It can cause serious birth defects and learning and developmental problems in the baby. Women who could become pregnant need effective contraception and specialist advice.

Will valproate make me gain weight?

Weight gain is common. A healthy diet and activity help; tell your doctor if it becomes a concern.

Do I need blood tests?

Yes, your doctor may check liver function and blood counts, especially early in treatment.

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Sources & further reading

Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.