Rifampicin: uses, side effects & brands

Written & medically reviewed by Dr. Sanjay Anbu, MBBS · Last reviewed 5 November 2026

Rifampicin is a core TB drug (also used for some other infections). It belongs to the Anti-tuberculosis (TB) medicine group. These treat tuberculosis. TB always needs a combination of drugs for several months to cure it and prevent resistance.

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Drug type — dosing is set by your doctor

Measure	Range
Drug class	Anti-tuberculosis (TB) medicine
Type	Prescription
Dose	Individual — ask your doctor or pharmacist

What it is used for

Core medicine for treating tuberculosis, always with other TB drugs
Treats leprosy as part of combination therapy
Used for some serious bacterial infections alongside other antibiotics
Given to close contacts to prevent certain meningitis infections

Common brand names

India: R-Cin, Rifald, Rimactane
Worldwide: Rifadin, Rimactane

Common side effects

Harmless orange-red colour of urine, sweat and tears
Nausea or loss of appetite
Flu-like symptoms with irregular use
Rash or itching

Before taking it — precautions

It weakens many medicines, including birth-control pills, blood thinners, HIV and diabetes medicines; tell your doctor about all medicines
Tell your doctor about liver disease or heavy alcohol use; liver tests may be done
Use a non-hormonal method of contraception during treatment

When to see a doctor urgently

Yellow skin or eyes, dark urine or persistent vomiting (urgent)
Unusual bruising or bleeding
Severe rash or allergic swelling (urgent)

Not a prescription — no dose shown. The right dose of rifampicin depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.

Frequently asked questions

Why is my urine orange-red?

Rifampicin colours body fluids orange-red. This is expected and harmless, but it can stain soft contact lenses.

Does it affect the contraceptive pill?

Yes. It makes hormonal contraceptives less effective, so use another method during treatment.

Can I stop once I feel better?

No. TB treatment must be completed in full to cure it and prevent drug resistance.

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Sources & further reading

Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.