Pentoxifylline: uses, side effects & brands

Written & medically reviewed by Dr. Sanjay Anbu, MBBS · Last reviewed 5 November 2026

Pentoxifylline improves blood flow in circulation problems of the legs. It belongs to the Peripheral vascular medicine group. These improve blood flow in the legs in peripheral artery disease and related conditions.

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Drug type — dosing is set by your doctor

Measure	Range
Drug class	Peripheral vascular medicine
Type	Prescription
Dose	Individual — ask your doctor or pharmacist

What it is used for

Leg pain on walking from poor circulation (intermittent claudication)
Venous leg ulcers (to help healing, alongside compression)
Some poor-circulation conditions

Common brand names

India: Trental, Flexital, Ptx
Worldwide: Trental, Pentoxil

Common side effects

Nausea or stomach upset
Dizziness
Headache
Flushing

Before taking it — precautions

Tell your doctor about recent bleeding, stroke or stomach ulcer
Tell your doctor if you take blood thinners or theophylline
Not for people allergic to caffeine-type medicines

When to see a doctor urgently

Unusual bleeding or black stools (urgent)
Chest pain or irregular heartbeat (urgent)
Severe rash or facial swelling (urgent)

Not a prescription — no dose shown. The right dose of pentoxifylline depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.

Frequently asked questions

How does pentoxifylline work?

It makes red blood cells more flexible and the blood thinner, helping it flow through narrow vessels.

Should I take it with food?

Yes, taking it with meals reduces stomach upset; swallow the tablets whole.

Is it the same as cilostazol?

Both are used for walking pain, but cilostazol is generally considered more effective.

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Sources & further reading

Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.