Esomeprazole: uses, side effects & brands

Written & medically reviewed by Dr. Sanjay Anbu, MBBS · Last reviewed 5 November 2026

Esomeprazole is a proton-pump inhibitor for reflux and ulcers. It belongs to the Acidity, antacid & gut medicine group. These treat acidity, indigestion, ulcers, spasm and bowel problems.

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Drug type — dosing is set by your doctor

Measure	Range
Drug class	Acidity, antacid & gut medicine
Type	Prescription
Dose	Individual — ask your doctor or pharmacist

What it is used for

Acid reflux and heartburn (GERD)
Stomach and duodenal ulcers
Healing a damaged food pipe (oesophagitis)
Part of H. pylori eradication treatment
Protecting the stomach in people on painkillers like NSAIDs

Common brand names

India: Nexpro, Esoz, Sompraz
Worldwide: Nexium

Common side effects

Headache
Nausea, tummy pain or wind
Diarrhoea or constipation

Before taking it — precautions

Take before a meal, usually in the morning
Long-term use may lower magnesium, vitamin B12 and bone strength — review with your doctor
Tell your doctor about other medicines, e.g. clopidogrel, methotrexate or HIV medicines

When to see a doctor urgently

Black, tarry stools or vomiting blood (urgent)
Difficulty swallowing or unexplained weight loss
Severe or persistent watery diarrhoea

Not a prescription — no dose shown. The right dose of esomeprazole depends on age, weight, kidney/liver function and the condition, so MedDroid does not show a dose here. Always get your dose from a doctor or pharmacist and the leaflet inside the pack. General educational information only.

Frequently asked questions

How is esomeprazole different from omeprazole?

Esomeprazole is a refined form of omeprazole; both work similarly to reduce stomach acid.

Can I take it for years?

Some people need it long-term, but your doctor should review whether you still need it and at the lowest effective dose.

When is it best to take?

Before a meal, usually breakfast, so it can block acid as the stomach starts making it.

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Sources & further reading

Reviewed by Dr. Sanjay Anbu, MBBS. MedDroid is an AI medical assistant and can make mistakes. It provides general health information, not a diagnosis or medical advice — always consult a qualified clinician. In an emergency, contact your local emergency number immediately.